regenie is a C++ program for whole genome regression modelling of large genome-wide association studies.

It is developed and supported by a team of scientists at the Regeneron Genetics Center.

The method has the following properties


Mbatchou, J., Barnard, L., Backman, J. et al. Computationally efficient whole-genome regression for quantitative and binary traits. Nat Genet 53, 1097–1103 (2021).


regenie is distributed under an MIT license.


If you have any questions about regenie please contact

If you want to submit a issue concerning the software please do so using the regenie Github repository.