regenie is a C++ program for whole genome regression modelling of large genome-wide association studies.

It is developed and supported by a team of scientists at the Regeneron Genetics Center.

The method has the following properties

Citation Joelle Mbatchou, Leland Barnard, Joshua Backman, Anthony Marcketta, Jack A. Kosmicki, Andrey Ziyatdinov, Christian Benner, Colm O'Dushlaine, Mathew Barber, Boris Boutkov, Lukas Habegger, Manuel Ferreira, Jeffrey Reid, Goncalo Abecasis, Evan Maxwell, Jonathan Marchini. (2020) Computationally efficient whole genome regression for quantitative and binary traits [BioRxiv pre-print]


regenie is distributed under an MIT license.


If you have any questions about regenie please contact

If you want to submit a issue concerning the software please do so using the regenie Github repository.